Activation by barium of constitutive nitric oxide synthase
نویسندگان
چکیده
منابع مشابه
Roles of constitutive nitric oxide synthase in postischemic rat retina.
PURPOSE Nitric oxide is a reactive species that could be protective or destructive to the retina depending on the stage of the evolving ischemic process. This study was conducted to obtain a better understanding of the roles of constitutive nitric oxide synthase (cNOS) during reperfusion after ischemia in rat retina. METHODS Retinal ischemia was induced for 60 minutes in Sprague-Dawley rats b...
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OBJECTIVE Increased formation of reactive oxygen species (ROS) has been identified as a causative factor in endothelial dysfunction by reducing NO bioavailability and uncoupling endothelial nitric oxide synthase (eNOS). However, the specific contribution of ROS to endothelial function is not well understood. METHODS AND RESULTS A major source of intracellular ROS is the NADPH oxidase (Nox) fa...
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The endothelial isoform of NO synthase (eNOS) is targeted to sphingolipid-enriched signal-transducing microdomains in the plasma membrane termed caveolae. Among the caveolae-targeted sphingolipids are the ceramides, a class of acylated sphingosine compounds that have been implicated in diverse cellular responses. We have explored the role of ceramide analogues in eNOS signaling in cultured bovi...
متن کاملConstitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation.
The physiological effects of nitroglycerin as a potent vasodilator have long been documented. However, the molecular mechanisms by which nitroglycerin exerts its biological functions are still a matter of intense debate. Enzymatic pathways converting nitroglycerin to vasoactive compounds have been identified, but none of them seems to fully account for the reported clinical observations. Here, ...
متن کاملIncreased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure.
OBJECTIVES The purpose of the present study was to examine the expression of the endothelial-type nitric oxide synthase (NOS III) and the inducible-type NOS (NOS II) in human myocardium and their regulation in heart failure from patients with different etiologies. BACKGROUND In heart failure, plasma levels of nitrates were found to be elevated. However, data on myocardial NOS expression in he...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1995
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)46352-x